Table 4:

Hazard Ratios and 95% CIs for Dosage Analyses

(Outcome: Self-Harms + Drug Overdoses Combined)

			Pre Period			Post Period
Exposure	Tx	# of Subjects	# of Events	PY	Rate/10K	# of Events	PY	Rate/10K	HR	95% CI
>= 1 Day	Op	16,65,032	1,476	24,67,139	5.98	1,556	18,92,702	8.22	1.23	1.06–1.43
	Bz	3,56,144	253	4,18,188	6.05	618	3,61,150	17.12	2.55	2.12–3.05
	Op+Bz	2,20,830	280	2,65,502	10.54	596	2,31,902	25.71	0.70	0.55–0.89
	No Rx	21,38,811	1,641	30,92,396	5.31	1,657	27,68,126	5.99
1–90 Days	Op	16,39,029	1,463	24,47,943	5.98	1,522	18,62,381	8.17	1.22	1.06–1.42
	Bz	3,15,548	219	3,93,766	5.57	460	3,17,840	14.47	2.33	1.92–2.83
	Op+Bz	2,15,011	273	2,63,654	10.34	570	2,25,555	25.26	0.55	0.59–0.99
	No Rx	21,38,811	1,641	30,92,396	5.31	1,657	27,68,126	5.99
91–180 Days	Op	15,666	4	12,865	3.49	19	17,327	11.05	2.88	0.73–11.36
	Bz	25,888	21	16,531	12.46	89	25,582	34.68	2.56	1.63–4.02
	Op+Bz	1,910	3	732	46.81	9	1,696	55.15	0.15	0.02–0.90
	No Rx	21,38,811	1,641	30,92,396	5.31	1,657	27,68,126	5.99
> 180 Days	Op	10,337	8	6,330	13.03	15	12,993	11.23	0.79	0.24–2.56
	Bz	14,708	13	7,892	16.53	70	17,728	39.43	2.21	1.25–3.91
	Op+Bz	3,909	4	1,115	32.58	17	4,651	36.92	0.62	0.11–3.45
	No Rx	21,38,811	1,641	30,92,396	5.31	1,657	27,68,126	5.99