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. Author manuscript; available in PMC: 2022 Nov 15.
Published in final edited form as: Circ Res. 2021 Oct 8;129(11):1006–1020. doi: 10.1161/CIRCRESAHA.120.317900

Figure 6. MSC-Exosome injection decreases the number of apoptotic cells in the myocardium and enhances inflammation resolution, 7-days post-MI.

Figure 6.

Representative immunofluorescent images (A) and bar graph (B) showing reduced number of TUNEL positive cardiomyocyte cells in MSC-Exo treated mice as compared to PBS-treated mice. n=3, P=0.002. The inset in each panel represents magnified view of boxed area (A1-A4). Scale bar, 20 μm. C and D, qRT-PCR analysis showing lower mRNA expression of pro-inflammatory-related genes (C) and a corresponding increase in anti-inflammatory-related genes (D) in the myocardium of mice receiving MSC-Exo compared to PBS-treated mice. Data normalized to GAPDH mRNA expression and shown as fold change vs MI+PBS group. n=3. We averaged the sample data that were derived from the same animal.