Enzymatic or oxygen radical catalyzed peroxidation of linoleic acid produces a variety of oxidized lipids including HpODEs, HODEs, oxoODEs, EpOMEs, DiHOMEs, as well as hydroxyl-epoxide and hydroxy-ketone derivatives. Hydroxy-epoxide derivatives of linoleic acid (not shown) can be converted to trihydroxy octadecenoates by soluble epoxide hydrolase or non-specific hydrolysis.