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. 2021 Nov 16;11:22317. doi: 10.1038/s41598-021-01739-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Results of bone histomorphometry. (a) Bone-to-implant contact (BIC); the DED group showed significantly higher BIC than the other groups 6 weeks after implantation, and higher BIC than the PBF group at 12 weeks. (b) Absent area; there was no significant difference across the three test groups at 6 and 12 weeks. (c) 500 µm bone area; the DED group showed higher osseointegration than the PBF group in 500-µm bone area at 6 weeks. (d) 1000 µm bone area; the DED group showed higher osseointegration than the TPS group at 6 and 12 weeks (*p < 0.05).