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. 2021 Nov 3;12:744747. doi: 10.3389/fendo.2021.744747

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Copyright © 2021 Ali, Pastrello, Kaur, Peffers, Ormseth and Jurisica

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Non-coding RNA network in OA chondrocytes. (A) Literature curated lncRNA-miRNA-gene and circRNA-miRNA-gene axes (green, turquoise, and brown arrows) complemented by physical protein interactions (blue nondirectional lines connecting gene products) showing an interconnected regulatory network of non-coding RNAs in human OA chondrocytes. Node shape represents different molecule types, while gene target color signifies Gene Ontology biological process (as indicated in the legend). (B) The largest connected subgraph from panel A considering only literature curated non-coding, directed interactions and including undirected protein interaction connections among the pertinent gene targets.