TABLE 3.

Body weight measurement of three mouse models.

	0 week	4 week	8 week	12 week	16 week
CD	17.0 (± 0.6) g	19.7 (± 1.0) g	20.0 (± 0.9) g	20.9 (± 1.0) g	22.6 (± 2.5) g
HFD	19.4 (± 0.8) g	24.8 (± 2.5) g****	29.1 (± 3.6) g****	33.1 (± 4.3) g****	37.6 (± 3.7) g****
	0 day	3 days	9 days	12 days	16 days
C	21.7 (± 1.7) g	22.8 (± 2.0) g	22.1 (± 2.1) g	21.5 (± 1.6) g	21.9 (± 1.9) g
L	21.8 (± 1.9) g	20.5 (± 1.9) g	19.0 (± 1.4) g**	18.5 (± 1.2) g***	19.4 (± 1.7) g
	8 week	9 week	10 week	11 week	12 week
ob/ob +/?	20.9 (± 1.6) g	21.5 (± 1.6) g	22.2 (± 1.6) g	22.8 (± 2.1) g	22.7 (± 2.1) g
ob/ob –/–	39.8 (± 5.4) g****	43.1 (± 5.0) g****	45.0 (± 4.7) g****	47.4 (± 5.7)****	48.8 (± 4.0) g****

DIO, Diet-induced obese; CD, mice were fed chow diet; HFD, high-fat diet (ii) pharmacologically hyperleptinemic mice were treated with saline (C) or leptin (L) for 16 days; (iii) genetically obese mice lacking leptin (ob/ob −/−) and control group (ob/ob +/?). Values presented in grams (g) of body weight and measurements made after weeks (wk) or days (d) within the specific protocol. Statistical analysis between groups was carried out using simple t-test. Asterisks indicate significant differences (**p < 0.01; ***p < 0.001; ****p < 0.0001).