. Author manuscript; available in PMC: 2022 Dec 20.

Published in final edited form as: Stat Med. 2021 Sep 22;40(29):6707–6722. doi: 10.1002/sim.9207

TABLE 4.

Model results for NYULH COVID-19 data application.

	PLSI GMRL^†			GMRL^†
	Estimate	95% CI^**		Estimate	95% CI^**
Baseline information (exponential of coefficient)
Age	1.12^*	1.09	1.15	1.12^*	1.09	1.15
Sex: Male	1.06^*	1.01	1.12	1.05^*	1.01	1.12
Race: White	1.02	0.97	1.07	1.02	0.97	1.07
logBMI	1.06	0.94	1.20	1.06	0.94	1.20
SpO₂	0.91^*	0.89	0.94	0.91^*	0.89	0.94
Temperature	0.98	0.96	1.01	0.99	0.96	1.01
Smoking: current/former	1.00	0.94	1.06	1.00	0.95	1.06
History of cardiac disease	1.06^*	1.02	1.12	1.06^*	1.01	1.11
History of pulmonary disease	1.02	0.94	1.09	1.02	0.94	1.09
History of diabetes	1.03	0.98	1.08	1.04	0.98	1.08
History of malignancy	1.11^*	1.02	1.21	1.11^*	1.01	1.21
Single-index component (coefficient)
Procalcitonin^‡	0.91^*	0.43	0.98	0.75^*	0.51	0.89
Troponin^‡	0.27^*	0.05	0.86	0.34^*	0.11	0.56
D-dimer^‡	0.32^*	0.01	0.57	0.40^*	0.16	0.60
Ferritin^‡	−0.01	−0.37	0.13	−0.02	−0.29	0.16
CRP^‡	0.06	−0.16	0.39	0.40^*	0.02	0.67

Estimated coefficient with p-value less than 0.05.

^**

95% confidence intervals were estimated by 1000 simulations.

^†

Pre-specified link function g(t) = exp(t) for both generalizedmean residual life model (GMRL) and partially linear single-index generalized mean residual life model (PLSI GMRL).

^‡

Biomarkers in single-index component were log-transformed and standardized.