Table 3.
General maternal anxiety during pregnancy and cord blood DNAm: associations with p-value below 5e-5.
| CpG site | Chr | Coordinate | P-value | Direction | N of Cohorts | N of Individuals | I2 | Heterogeneity p-value | Illumina annotated gene |
|---|---|---|---|---|---|---|---|---|---|
| cg08480774 | 16 | 85676306 | 1.79E-06 | ++−−−+++++++++− | 15 | 6653 | 23.7 | 0.19 | KIAA0182 |
| cg11062417 | 5 | 76578232 | 2.94E-06 | +++−−+++++++−−+ | 15 | 6676 | 6.1 | 0.38 | PDE8B |
| cg13516541 | 14 | 105239354 | 7.25E-06 | +−+??++++++++−+ | 13 | 6395 | 34.8 | 0.10 | AKT1 |
| cg02535219 | 16 | 11876908 | 9.23E-06 | +++++−++++++++− | 15 | 6675 | 0 | 0.55 | ZC3H7A |
| cg02070077 | 6 | 168199753 | 1.36E-05 | ++−+−+++++++−?+ | 14 | 6501 | 0 | 0.61 | - |
| cg01987516 | 10 | 101282726 | 1.73E-05 | −−−+−+−−−−−−−−− | 15 | 6669 | 0 | 0.68 | - |
| cg12891178 | 10 | 135085127 | 2.54E-05 | +++++−−++++−+++ | 15 | 6596 | 37.5 | 0.07 | ADAM8 |
| cg03713570 | 16 | 30789484 | 2.97E-05 | ++++++++++++−+− | 15 | 6662 | 0 | 0.45 | - |
| cg04618969 | 7 | 101848538 | 3.04E-05 | +++−++++−−++−++ | 15 | 6675 | 15.9 | 0.28 | CUX1 |
| cg02318282 | 5 | 82789386 | 3.17E-05 | +−++++?++++++−+ | 14 | 5481 | 18.1 | 0.26 | VCAN |
| cg14776033 | 19 | 49240808 | 3.24E-05 | ++−++++++++++?+ | 14 | 6515 | 0 | 0.60 | RASIP1 |
| cg26540370 | 19 | 1374742 | 3.38E-05 | +++++++++++++++ | 15 | 6668 | 0 | 0.53 | MUM1 |
| cg06710735 | 3 | 48264567 | 4.86E-05 | +−+?+++++++++−+ | 14 | 6577 | 0 | 0.60 | CAMP |
| cg27622017 | 3 | 181447418 | 4.87E-05 | −−−−−+−−−−−−−−− | 15 | 6679 | 0 | 0.93 | SOX2OT |
| cg19767020 | 1 | 164582668 | 4.88E-05 | +++++++++++++−+ | 15 | 6655 | 0 | 0.77 | PBX1 |
Abbreviations: Chr: chromosome; Direction: direction of effect per cohort, in which + signifies a positive effect estimate, - signifies a negative effect estimate, and ? refers to a lack of effect estimate in the particular study due to lack of data on the methylation of the specific site (cohorts are listed in alphabetical order: ALSPAC, BiB-1, BiB-2, DCHS-450k, DCHS-EPIC, EDEN, Generation R, GOYA, MoBa-1, MoBa-2, PREDO-450k, PREDO-EPIC, PRISM, PROGRESS); I2: this heterogeneity statistic describes the variation attributable to heterogeneity across studies (high I2 values suggest high heterogeneity); N of cohorts: number of cohorts included in analysis; N of Individuals: number of mother-child dyads included in the analysis; p-value: meta-analytic p-value for association between DNA methylation at the CpG site in question and anxiety)