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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Biochim Biophys Acta Rev Cancer. 2021 Sep 22;1876(2):188628. doi: 10.1016/j.bbcan.2021.188628

Figure 1.

Figure 1.

Schematic of CXCR3 chromosomal organization and signaling. Top). CXCR3 is located on the X chromosome and is composed of two exonic segments. Differential splicing of CXCR3 gives rise to three described splice variants A, B and Alt. CXCR3B is encoded entirely by a retained intronic sequence and exon 2. Bottom) CXCR3 A and B signaling is mediated by heterotrimeric G proteins (HTGP). CXCR3A couples with Gai/q and results in downstream activation of Ras/Raf/ Erk as well as PI3K/Akt signaling leading to cell proliferation, survival, and migration/invasion. CXCR3B signals through Gas resulting in activation of adenyl cyclase and PKA as well as p38 and p21 activation leading to sensitization of cells to death.