. Author manuscript; available in PMC: 2022 Dec 1.

Published in final edited form as: Biochim Biophys Acta Rev Cancer. 2021 Sep 22;1876(2):188628. doi: 10.1016/j.bbcan.2021.188628

Table 1.

Summary of the Direct Roles of CXCR3 in Metastasis.

Cancer	Splice Variant	Cellular Function	Citations
Prostate	CXCR3A	Augment invasion and proliferation	[46,47]
Prostate	CXCR3B	Suppress invasion and proliferation	[46,47]
Melanoma	CXCR3A	Augment invasion and brain metastasis in vivo	[41,50–52]
Colorectal	CXCR3A	Increased proliferation invasion, migration, lymph node and tail-vein metastasis	[29,42,59–62]
Colorectal	CXCR3B	Inhibition of proliferation, invasion and migration	[63]
Breast	CXCR3A	Increased migration, and cardiac -injection bone metastasis	[72, 74, 94]
Breast	CXCR3B	Increased Cancer Stem Cell Features and in vivo metastasis	[65, 95]
Ovarian	CXCR3	Increased migration to malignant ascites	[98]
Gastric	CXCR3A	Increased migration, invasion, and liver metastases	[28, 102]
Hepatocellular Carcinoma	CXCR3	Increased invasion, migration, tail-vein lung metastases	[103–105]
Pancreatic	CXCR3A	Increased invasion	[36,37]
Lung	CXCR3	Stimulate migration	[125]
Renal Cell Carcinoma	CXCR3A	Induced migration	[32]
Renal Cell Carcinoma	CXCR3B	Suppressed proliferation Increased Apoptosis	[24,129]