Table 2.

Summary of Immunologic functions of CXCR3.

Cancer	Function	Consequences	Citations
Prostate	CD4+ T-cell recruitment	Increased cancer cell invasion	[49]
Melanoma	CD8+ T-cell Recruitment, Suppress T-reg function	Decreased metastasis	[54–58]
	Increased PD-L1 expression in cancer cells	Decreased immune infiltrate	[53]
Colorectal	Associated with increased Th1 and CD8+ signatures	and associated with reduced TNM stage	[69–71]
	Increased NK-cell infiltrate	Reduced tumor growth and metastasis in mice	[71]
Breast	Increased NK-cell recruitment, Decreased myeloid cell infiltrate	Increased tail-vein metastasis	[72–74]
	Increased CD4+ T-cell and NK-cell recruitment	Reduced tumor growth and metastasis	[89–91]
Ovarian	Recruitment of Tregs	Undetermined	[99]
	Associated with increased number of T-cells and NK cells	Associated with increased survival	[100]
Gastric	Positively associated with increased CD4+ and CD8+ infiltrates	Associated with increased overall survival	[75, 76]
	Increased PD-L1 expression in cancer cells	Undetermined	[16]
Hepatocellular Carcinoma	Increased Treg recruitment	Increased likelihood of tumor recurrence	[81]
	Increased alternative macrophage activation	Suppressed anti-tumor immune response	[82]
	Alternate macrophage polarization	Suppressed anti-tumor immune response	[83]
Pancreatic Cancer	T-reg recruitment	Association with poor prognosis	[85,86]
	Suppressed CD8+ T-cell function	Association with poor outcome and more rapid tumor progression in mice	[84, 87]