Table 1.

Summary of the 316 unique metabolic traits (with a significant heritability) analyzed in this study per metabolite superclasses and classes

Superclass (no. of metabolites)	Class (no. of metabolites)	Sample size	${\mathit{h}}_{\mathit{SNP}}^2$range	${\mathit{h}}_{\mathit{SNP}}^2$SE range	${\mathit{h}}_{\mathit{SNP}}^2$median	${\mathit{h}}_{\mathit{SNP}}^2$SE median
Lipids and lipid-like molecules (189)	lipoprotein lipids (82)	6,263–24,925	0.05–0.38	0.02–0.12	0.12	0.03
	fatty acyls (39)	7,478–24,925	0.07–0.57	0.04–0.14	0.21	0.07
	glycerophospholipids (24)	6,263–7,824	0.1–0.33	0.05–0.09	0.17	0.07
	lipid features (24)	6,263–24,925	0.05–0.36	0.03–0.12	0.14	0.03
	steroids and steroid derivatives (10)	6,263–7,824	0.16–0.51	0.06–0.3	0.26	0.09
	lipid ratios (4)	6,263	0.18–0.2	0.09–0.11	0.19	0.09
	glycerolipids (3)	7,824–24,925	0.12–0.35	0.03–0.08	0.18	0.07
	sphingolipids (3)	7,478–7,824	0.12–0.43	0.06–0.07	0.14	0.07
Organic acids and derivatives (42)	carboxylic acids and derivatives (32)	6,263–24,925	0.06–1	0.02–0.12	0.34	0.07
	keto acids and derivatives (4)	7,824–24,925	0.07–0.71	0.03–0.08	0.22	0.06
	hydroxy acids and derivatives (3)	7,824–24,925	0.04–0.36	0.02–0.08	0.11	0.06
	organic sulfuric acids and derivatives (2)	7,824	0.16–0.18	0.06–0.06	0.17	0.06
	organic phosphoric acids and derivatives (1)	7,824	0.15	0.07	0.15	0.07
Organic oxygen compounds (8)	organooxygen compounds (8)	7,824–24,925	0.09–0.51	0.02–0.12	0.28	0.07
Organoheterocyclic compounds (6)	imidazopyrimidines (3)	7,824	0.16–0.21	0.06–0.08	0.2	0.07
	indoles and derivatives (2)	7,824	0.14–0.35	0.06–0.07	0.25	0.07
	oxepanes (1)	7,824	0.22	0.13	0.22	0.13
Organic nitrogen compounds (3)	organonitrogen compounds (3)	6,263–7,824	0.19–1	0.08–0.09	0.25	0.09
Benzenoids (2)	benzene and substituted derivatives (1)	7,824	0.39	0.07	0.39	0.07
	phenols (1)	7,824	1	0.36	1	0.36
Nucleosides, nucleotides, and analogs (2)	purine nucleosides (2)	7,824	0.48–0.71	0.05–0.1	0.59	0.08
Homogeneous non-metal compounds (1)	non-metal oxoanionic compounds (1)	7,824	0.35	0.05	0.35	0.05
Phenylpropanoids and polyketides (1)	phenylpropanoic acids (1)	7,824	0.23	0.06	0.23	0.06
Unknown (62)	unknown (62)	7,824	0.11–1	0.04–0.54	0.3	0.07

$h_{SNP}^2$, SNP heritability; SE, standard error of SNP heritability.