Table 2.

Metabolic traits with a causal effect on migraine identified by LCV model

Metabolic trait	Superclass	Class	GCP	SE	Adjusted p
X-11315	unknown	unknown	0.37	0.05	8 × 10−12
LPE(20:4)	lipids and lipid-like molecules	glycerophospholipids	0.70	0.19	1 × 10−9
LPC(20:2)	lipids and lipid-like molecules	glycerophospholipids	0.67	0.07	6 × 10−8
Free cholesterol in IDL	lipids and lipid-like molecules	lipoprotein lipids	0.25	0.35	4 × 10−6
Fatty acid length	lipids and lipid-like molecules	lipid features	0.45	0.16	2 × 10−5

Full LCV model results for all 79 tested metabolic traits (identified in genetic overlap analyses) are available in Table S5. LPE, lysophosphatidylethanolamine; LPC, lysophosphatidylcholine; GCP and SE, posterior mean genetic causality proportion and posterior standard error estimated by the LCV model; Adjusted p, p values tested the null hypothesis of no genetic causality and were adjusted with the Bonferroni method.