Table 2.

Individuals with vision loss attributable to LHON

LHON mutation	Males with vision loss/ total carriersa[penetrance]	Females with vision loss/total carriersa[penetrance]	Total individuals with vision loss/total carriersa[penetrance]
m.11778G>A	309/1,902 [16.2%]	91/2,084 [4.3%]	400/3,986 [10.0%]
m.14484T>C	104/564 [18.4%]	22/651 [3.4%]	126/1,215 [10.4%]
m.3460G>A	16/89 [18.0%]	5/87 [5.7%]	21/176 [11.9%]
m.4171C>A	1/5 [20.0%]	1/7 [14.3%]	2/12 [16.7%]
m.14482C>G	5/22 [22.7]	2/32 [6.2%]	7/54 [13.0%]
m.11778G>A/m.14484T>C	1/16 [6.2%]	2/25 [8.0%]	3/41 [7.3%]
m.14484T>C/m.4160T>C	26/35 [74.3%]	35/49 [71.4%]	61/84 [72.6%]
Total	462/2,633 [17.5%]	158/2,935 [5.4%]	620/5,568 [11.1%]

^aOnly asymptomatic carriers over 25 years of age are included.