Table 3.
Associations between mtDNA haplogroup and vision loss
Number (%) with vision loss | Adjusted OR | Adjusted 95% CI | Adjusted p value | |
---|---|---|---|---|
Total | 526/5,201 (10.1%) | – | – | – |
Sex | ||||
Female | 113/2,736 (4.1%) | 1.00 | – | – |
Male | 413/2,465 (16.8%) | 4.81 | [3.75, 6.16] | <0.001 |
Mutation | ||||
11778 | 400/3,986 (10.0%) | 1.00 | – | – |
14484 | 126/1,215 (10.4%) | 0.57 | [0.41, 0.79] | 0.001 |
Haplotype | ||||
H | 208/2,797 (7.4%) | 1.00 | – | – |
J | 197/1,429 (13.8%) | 2.85 | [2.04, 3.99] | <0.001 |
Other | 73/700 (10.4%) | 1.73 | [1.06, 2.81] | 0.028 |
Unknown | 48/275 (17.5%) | 2.92 | [1.77, 4.80] | <0.001 |
Multivariable logistic regression estimated with all listed variables as covariates and robust standard errors to account for intra-family correlation.