Skip to main content
. 2021 Oct 19;108(11):2159–2170. doi: 10.1016/j.ajhg.2021.09.015

Table 3.

Associations between mtDNA haplogroup and vision loss

Number (%) with vision loss Adjusted OR Adjusted 95% CI Adjusted p value
Total 526/5,201 (10.1%)

Sex

Female 113/2,736 (4.1%) 1.00
Male 413/2,465 (16.8%) 4.81 [3.75, 6.16] <0.001

Mutation

11778 400/3,986 (10.0%) 1.00
14484 126/1,215 (10.4%) 0.57 [0.41, 0.79] 0.001

Haplotype

H 208/2,797 (7.4%) 1.00
J 197/1,429 (13.8%) 2.85 [2.04, 3.99] <0.001
Other 73/700 (10.4%) 1.73 [1.06, 2.81] 0.028
Unknown 48/275 (17.5%) 2.92 [1.77, 4.80] <0.001

Multivariable logistic regression estimated with all listed variables as covariates and robust standard errors to account for intra-family correlation.