Table 4.

Vision loss in offspring of affected women with LHON

Affected mother mutation	Males with vision loss/total male offspringa[penetrance]	Females with vision loss/total female offspringa[penetrance]	Total individuals with vision loss/total offspringa[penetrance]
m.11778G>A	30/87 [34.5%]	10/91 [11%]	40/178 [22%]
m.14484T>C	3/19 [15.8%]	5/21 [23.8%]	8/40 [20%]
m.3460G>A	0/1 [N/A]	1/3 [33.3%]	1/4 [25%]
m.14484T>C/m.4160T>C	15/24 [62.5%]	27/32 [84.4%]	42/56 [75%]
m.14482C>G	1/1 [100%]	1/2 [50%]	2/3 [66.6%]
Total	49/132 [37.1%]	44/149 [29.5%]	93/281 [33.1%]

N/A, not applicable.

^aOnly asymptomatic carriers over 25 years of age are included.