Table 6.
Falling rate of vision loss among males from the largest Australian LHON pedigree, TAS01
| Generation with earliest year of male birth | This study (full genealogical ascertainment) | Mackey and Howell19 | Hamilton39“pedigree 33” | Hogg38 |
|---|---|---|---|---|
| IV b1804 | 3 of 4 (75%) | 3 of 4 (75%) | 3 of 3 (100%)a | 3 of 3 (100%)b |
| V b1823 | 4 of 19 (21%) | 4 of 17 (24%) | 5 of 5 (100%) | 3 of 15 (20%) |
| VI b1844 | 13 of 105 12%) | 12 of 86 (14%) | 7 of 18 (39%) | N/A |
| VII | 27 of 202 (13%) | 27 | 7 of 21 (33%) | N/A |
| VIII | 26 of 180 (14%) | 22 | N/A | N/A |
| IX | 26 of 229 (11%) | 21 | N/A | N/A |
| X | 11 of 209 (5%) | 2 | N/A | N/A |
Number of individuals with vision loss and penetrance (%) are shown for each generation. N/A, not applicable.
a
Two sub-matriarchs missing.
b
One missing unaffected man who moved to Melbourne.