Table 3.
Pathway map enrichment with disease biomarkers.
| Pathway Map Name | BTK | TEC | ITK | BMX | TXK | JAK3 | EGFR | SLE | RA | MS | SJ |
|---|---|---|---|---|---|---|---|---|---|---|---|
| p-value | p-value | p-value | p-value | ||||||||
| Chemotaxis_CXCL12/CXCR4-induced chemotaxis of immune cells | 8.28E-08 | 2.44E-05 | 3.01E-03 | 2.41E-03 | |||||||
| Role of tumor-infiltrating B cells in anti-tumor immunity | 3.33E-25 | 4.25E-21 | 1.55E-16 | 7.66E-29 | |||||||
| Immune response_NF-AT in immune response | 5.40E-12 | 3.25E-07 | 1.34E-03 | 3.95E-03 | |||||||
| Immune response_IL-6 signaling pathway via MEK/ERK and PI3K/AKT cascades | 2.24E-08 | 1.16E-07 | 5.01E-04 | 3.42E-04 | |||||||
| Immune response_PIP3 signaling in B lymphocytes | 1.42E-02 | 3.68E-02 | NA | NA | |||||||
| Role of B cells in SLE | 1.39E-28 | 9.93E-30 | 2.17E-18 | 2.97E-26 | |||||||
| SLE genetic marker-specific pathways in B cells | 2.51E-24 | 2.66E-14 | 4.12E-11 | 6.54E-10 | |||||||
| B cell signaling in hematological malignancies | 1.55E-18 | 1.64E-13 | 8.03E-07 | 1.15E-08 | |||||||
| Immune response_Fc epsilon RI pathway: Lyn-mediated cytokine production | 4.65E-18 | 2.04E-09 | 5.00E-05 | 3.77E-08 | |||||||
| IgE- and MGF-induced Lyn-mediated production of cytokines and arachidonic acid metabolites in lung mast cells in asthma | 1.47E-17 | 5.94E-09 | 8.95E-06 | 1.05E-04 | |||||||
| Immune response_IL-5 signaling via PI3K, MAPK and NF-κB | 5.41E-12 | 9.14E-12 | 1.71E-04 | 4.18E-04 | |||||||
| Immune response_B cell antigen receptor (BCR) pathway | 1.37E-10 | 6.13E-06 | NA | 1.06E-04 | |||||||
| Immune response_BAFF-induced canonical NF-κB signaling | 3.88E-07 | 1.46E-08 | 1.73E-03 | 3.98E-07 | |||||||
| Cell adhesion_Integrin inside-out signaling in neutrophils | 1.83E-05 | 5.68E-05 | 2.45E-03 | 4.61E-04 | |||||||
| Immune response_TLR3 and TLR4 induced TICAM1-specific signaling pathway | 2.31E-05 | 4.89E-07 | 2.92E-02 | 4.38E-05 | |||||||
| Proinflammatory mediators release and arachidonic acid metabolites production in basophils in asthma | 1.21E-03 | 4.03E-05 | 1.02E-02 | 2.72E-02 | |||||||
| Blood coagulation_GPVI-dependent platelet activation | 2.53E-03 | 3.35E-03 | NA | NA | |||||||
| G-protein signaling_G-Protein alpha-q signaling cascades | 3.78E-03 | 3.38E-02 | NA | NA | |||||||
| Production of reactive oxygen species and arachidonic acid metabolites by neutrophils in asthma | 1.50E-02 | 1.19E-03 | 9.73E-03 | 1.58E-02 |
Enrichment results generated using pathway map enrichment analysis in MetaCore. Left side shows the presence of the target/off-target on the map and the right corner shows the p-value for the biomarker list colored as: Highly significant in red, mid value in yellow and low significance in green.