TABLE 1.

Transcriptional regulation in mammalian corticogenesis.

Developmental process	Transcription factor	Regulated targets
Proliferation	CTNB1 Faux et al., 2012 transcriptional co-activation WNT/β-catenin Ahmed et al., 2009 HES1/5 Ahmed et al., 2009 GLI1-3 Ahmed et al., 2009 SOX1-3 Ahmed et al., 2009 REST Ahmed et al., 2009 SOX9 Fabra-Beser et al., 2021 YAP1 Fabra-Beser et al., 2021 PAX6 Sansom et al., 2009	Tcf/Lef, Fgf2 Ahmed et al., 2009 Sox2, Hes1, Hes5, Notch1, Cd133, Bmi-1 Ahmed et al., 2009 Sox9 Fabra-Beser et al., 2021 Neurog2, Ascl1, Hes1 Sansom et al., 2009
Differentiation	INSM1 Hevner, 2019 NEUROD2* Guzelsoy et al., 2019 FEZF2* Lai et al., 2008 CTIP2* Lai et al., 2008 TBR1/2* Hevner, 2019 CUX1/CUX2° Faux et al., 2012 DLX1,2,5,6° Faux et al., 2012 LHX6,8° Faux et al., 2012 MASH1° Faux et al., 2012 PAX6° Zimmer-Bensch, 2018 SOX2° Zimmer-Bensch, 2018 CBF1 Ahmed et al., 2009	Neurod1 Hevner, 2019 Pax6, Insm,1 Robo2, Fog2, Zfp423 Hevner, 2019 Zeb2 McKinsey et al., 2013 Sox2, Nanog, Hes1 Zimmer-Bensch, 2018 Ascl1, Dlx1 Zimmer-Bensch, 2018
Specific interneuron lineage fate MGE-derived CGE-derived POA-derived	ZEB2 Zimmer-Bensch, 2018 NKX2.1 Sussel et al., 1999; Du et al., 2008; Faux et al., 2012 LHX6 Liodis et al., 2007; Faux et al., 2012; Neves et al., 2013 NKX6.2 SOX6 Batista-Brito et al., 2009; Faux et al., 2012; Wamsley and Fishell, 2017 SIP1 van den Berghe et al., 2013; Wamsley and Fishell, 2017 SATB1 Close et al., 2012; Denaxa et al., 2012; Wamsley and Fishell, 2017 Coup-TFI/II Zimmer-Bensch, 2018 Coup-TFI/II Faux et al., 2012 PROX1 Miyoshi et al., 2015; Zimmer-Bensch, 2018 SP8 Zimmer-Bensch, 2018 NR2F2 Zimmer-Bensch, 2018 NKX5.1/HMX3 Gelman et al., 2009; Gelman and Marín, 2010 LHX1 Symmank et al., 2019 NKX6.2 Flames et al., 2007; Gelman et al., 2009; Gelman and Marín, 2010	Nkx2.1, cMaf, Cxcr7 Zimmer-Bensch, 2018 Lhx6 Du et al., 2008 Arx, Cxcr7, Sox6, Satb1 Zimmer-Bensch, 2018 Sox6 Zimmer-Bensch, 2018
	DBX1 Flames et al., 2007; Gelman et al., 2009; Gelman and Marín, 2010
Interneurons tangential migration	ZEB2 McKinsey et al., 2013; Zimmer-Bensch, 2018 Coup-TFI/II Faux et al., 2012; Zimmer-Bensch, 2018 DCX Faux et al., 2012 DLX1,2 Faux et al., 2012 LHX6 Faux et al., 2012; Zimmer-Bensch, 2018	Unc5b McKinsey et al., 2013; Zimmer-Bensch, 2018 Arx, Cxcr7 Zimmer-Bensch, 2018
Interneuron guidance through ventral telencephalon	LHX1 Symmank et al., 2019	Epha4, efnB3 Symmank et al., 2019
Radial migration	SOX5* Lai et al., 2008 NGN2* Hand and Polleux, 2011 MEF2C* Hand and Polleux, 2011 NEUROD1* Hand and Polleux, 2011 NEUROD2* Hand and Polleux, 2011 SOX6° Faux et al., 2012 KIR2.1° García et al., 2011; Wamsley and Fishell, 2017	Rnd2 Hand and Polleux, 2011 Rnd2 Hand and Polleux, 2011
Cortical lamination	NPAS4* Spiegel et al., 2014; Wamsley and Fishell, 2017 FEZF2* Tantirigama et al., 2016 SOX5* Lai et al., 2008 CUX1/2* Cubelos et al., 2010 ETV1* Sorensen et al., 2015 OTX1* Arlotta et al., 2005; Lai et al., 2008 ER81* Arlotta et al., 2005 SOX6° Zimmer-Bensch, 2018 LHX1° Zimmer-Bensch, 2018 SATB1° Denaxa et al., 2012; Wamsley and Fishell, 2017 KCC2/SLC12A5° Bortone and Polleux, 2009; Wamsley and Fishell, 2017 MEF2C° Mao et al., 1999; Wamsley and Fishell, 2017 NPAS4° Spiegel et al., 2014; Wamsley and Fishell, 2017	Bdnf Wamsley and Fishell, 2017 Xlr3b, Xlr4b Cubelos et al., 2010 Bdnf Wamsley and Fishell, 2017

This table provides an overview of transcription factors and their target genes, as well as of other relevant proteins such as KCC2/SLC12A5, being implicated in distinct aspects of corticogenesis. Annotation:

* excitatory neurons;

° interneurons.