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. 2021 Nov 10;16:7497–7515. doi: 10.2147/IJN.S321071

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© 2021 Huang et al.

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In vivo and acute toxicity and immunogenicity. Mice were intravenously administered a high dosage of different formulations (30 mg/kg DOX), and blood samples were collected at 12 and 24 hours after administration. (A) RBC, (B) WBC, (C) PLT, (D) MPV, (E) MCV, (F) HGB levels and (G–I) serum levels of the main proinflammatory cytokines (IL-1β, IL-6, and TNF-α). Bars are represented as SD, ^n.s p > 0.05, *p < 0.05, **p < 0.01 (n=3).