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. 2021 Nov 16;9(2):e002039. doi: 10.1136/bmjdrc-2020-002039

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Individual M values across the 60 individuals, arranged by increasing order. (B) Mean±SEM of M values grouped into three groups: least sensitive (M≤6), intermediate sensitive (M=6.1–12) and most sensitive (M>12). One-way analysis of variance followed by Bonferroni statistical test was performed for multiple comparisons. *P<0.001 versus the least sensitive group. (C) Insulin concentrations during the clamp procedure and (D) AUC for insulin concentrations during the clamp procedure. AUC, area under the curve; Ins, insulin; M value, whole-body glucose disposal rate.