Table 3.
Pearson correlations of M value calculated from the hyperinsulinemic-euglycemic clamp and insulin secretion (AUC) during OGTT with demographics and fasting biochemical data
| M value | OGTT-Ins-AUC | HOMA2-IR | ||||
| r | P value | r | P value | r | P value | |
| Age | −0.161 | 0.218 | 0.182 | 0.167 | 0.1925 | 0.1514 |
| Weight (kg) | 0.035 | 0.793 | 0.01 | 0.942 | −0.0195 | 0.8858 |
| Height (cm) | −0.129 | 0.327 | −0.104 | 0.433 | −0.095 | 0.483 |
| BMI (kg/m2) | 0.135 | 0.303 | 0.086 | 0.519 | 0.024 | 0.857 |
| Waist (cm) | 0.191 | 0.37 | 0.015 | 0.947 | 0.091 | 0.687 |
| SBP (mm Hg) | 0.053 | 0.693 | 0.063 | 0.644 | 0.003 | 0.986 |
| DBP (mm Hg) | −0.133 | 0.318 | 0.182 | 0.176 | 0.208 | 0.127 |
| HR (beats per minute) | −0.232 | 0.079 | 0.144 | 0.284 | 0.461** | 0.000 |
| Hb (g/L) | −0.330* | 0.011 | 0.198 | 0.137 | 0.223 | 0.098 |
| Cre (µmol/L) | 0.081 | 0.541 | −0.171 | 0.195 | −0.219 | 0.101 |
| Albumin (g/L) | −0.284* | 0.029 | 0.102 | 0.445 | 0.067 | 0.622 |
| Platelets (×109/L) | −0.165 | 0.212 | 0.001 | 0.431** | 0.207 | 0.126 |
| ALT (U/L) | −0.139 | 0.29 | 0.461** | 0.0001 | 0.378** | 0.004 |
| AST (U/L) | 0.063 | 0.638 | 0.155 | 0.246 | 0.081 | 0.553 |
| T chol (mmol/L) | −0.233 | 0.079 | 0.522** | 0.0001 | 0.254 | 0.059 |
| TG (mmol/L) | −0.265* | 0.044 | 0.531** | 0.0001 | 0.231 | 0.086 |
| HDL (mmol/L) | −0.078 | 0.562 | −0.09 | 0.502 | −0.109 | 0.423 |
| LDL (mmol/L) | −0.186 | 0.162 | 0.503** | 0.0001 | 0.274* | 0.041 |
| FBG (mmol/L) | −0.011 | 0.932 | 0.032 | 0.813 | −0.059 | 0.674 |
| HbA1c (%) | 0.213 | 0.106 | −0.05 | 0.708 | −0.171 | 0.208 |
| TSH (mIU/L) | −0.012 | 0.931 | 0.13 | 0.336 | −0.205 | 0.133 |
| Insulin | −0.336* | 0.045 | 0.343* | 0.041 | 0.370* | 0.031 |
| Region (%fat) | −0.212 | 0.103 | 0.345** | 0.007 | 0.350** | 0.008 |
| Total mass (kg) | −0.008 | 0.954 | 0.011 | 0.937 | −0.027 | 0.842 |
| Tissue (g) | −0.013 | 0.923 | 0.027 | 0.838 | −0.015 | 0.912 |
| Fat (g) | −0.108 | 0.412 | 0.291* | 0.026 | 0.240 | 0.073 |
| Lean mass (g) | 0.147 | 0.263 | −0.213 | 0.105 | −0.242 | 0.069 |
| BMC (g) | 0.03 | 0.818 | −0.217 | 0.099 | −0.141 | 0.297 |
| Fat-free mass (g) | 0.143 | 0.277 | −0.347** | 0.007 | −0.243 | 0.069 |
| Android (%fat) | −0.235 | 0.071 | 0.449** | 0 | 0.346** | 0.008 |
| Gynoid (%fat) | −0.066 | 0.615 | 0.219 | 0.095 | 0.270* | 0.042 |
| A:G ratio | −0.186 | 0.155 | 0.145 | 0.274 | 0.047 | 0.728 |
| Total (%fat) | −0.201 | 0.124 | 0.351** | 0.006 | 0.352** | 0.007 |
| Glu-AUC | −0.09 | 0.496 | 0.162 | 0.22 | 0.084 | 0.536 |
| Ins-AUC | −0.416** | 0.001 | 1 | 0.563** | 0.000 | |
| C pep-AUC | −0.219 | 0.096 | 0.244 | 0.063 | 0.284* | 0.032 |
| M value | 1 | −0.416** | 0.001 | −0.255 | 0.056 | |
| Adiponectin (µg/mL) | 0.058 | 0.669 | −0.301* | 0.024 | −0.280* | 0.041 |
| Adipsin (µg/mL) | −0.047 | 0.731 | 0.088 | 0.52 | −0.088 | 0.526 |
| CRP (ng/mL) | −0.329* | 0.013 | 0.384** | 0.004 | 0.434** | 0.001 |
| TNFRSF1B (ng/mL) | 0.036 | 0.789 | 0.033 | 0.805 | 0.133 | 0.332 |
| sRAGE (ng/mL) | −0.102 | 0.442 | −0.072 | 0.586 | −0.212 | 0.114 |
| Oxidized LDL | −0.059 | 0.658 | 0.257* | 0.05 | 0.154 | 0.254 |
| TAC (U/L) | −0.171 | 0.194 | 0.159 | 0.229 | −0.108 | 0.423 |
| GPX-1 (ng/mL) | 0.003 | 0.984 | −0.08 | 0.551 | −0.090 | 0.509 |
| TIMP-1 (ng/mL) | −0.202 | 0.132 | 0.087 | 0.526 | 0.161 | 0.245 |
| PIIINP (µg/mL) | 0.196 | 0.144 | −0.1 | 0.461 | −0.020 | 0.888 |
| HA (ng/mL) | −0.278* | 0.036 | −0.102 | 0.455 | −0.129 | 0.354 |
| ELF score | −0.167 | 0.217 | −0.246 | 0.07 | −0.135 | 0.336 |
| NAFLD score | 0.233 | 0.138 | −0.367* | 0.018 | −0.235 | 0.149 |
Region (%fat) is % of fat present in the legs and trunk region. Tissue (g) is total body weight minus bone mineral content.
*p<0.05 and **p<0.01.
A:G, android to gynoid % fat ratio; ALT, alanine transaminase; AST, aspartate aminotransferase; AUC, area under the curve; BMC, bone marrow concentration; BMI, body mass index; C pep-AUC, C peptide area under curve; Cre, creatinine; CRP, C reactive protein; DBP, diastolic blood pressure; ELF, enhanced liver fibrosis; FBG, fasting blood glucose; Glu-AUC, glucose area under curve; GPX-1, glutathione peroxidase 1; HA, hyaluronic acid; Hb, hemoglobin; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; HOMA2-IR, Homeostatic Model Assessment 2 for Insulin Resistance; HR, heart rate; Ins-AUC, insulin area under curve; LDL, low-density lipoprotein; M value, whole-body glucose disposal rate; NAFLD, non-alcoholic fatty liver disease; OGTT, oral glucose tolerance test; PIIINP, procollagen III amino-terminal peptide; SBP, systolic blood pressure; sRAGE, soluble receptor for advanced glycation end products; TAC, total antioxidant capacity; T chol, total cholesterol; TG, triglycerides; TIMP-1, tissue inhibitor of metalloproteinase 1; TNFRSF1B, soluble tumor necrosis factor alpha receptor 2B; TSH, thyroid stimulating hormone.