Table 4.
Comparison of CYP2E1 genotype polymorpshim in the Western region of Saudi Arabia compared to other populations.
| Genotype |
Saudis (Western Region) |
Saudis (Central Region) |
Turkish |
Iranians |
South Indian (Tamilians) |
Caucasians |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | n | % | n | % | n | % | |
| CYP2E1*1B | 140 | NR |
NR | NR | 123 (NS) |
375 (P < 0.001) |
||||||
| A2A2 | 76 | 54.29 | – | – | – | 75 | 61 | 279 | 75 | |||
| A2A1 | 56 | 40 | 44 | 35.8 | 91 | 24 | ||||||
| A1A1 | 8 | 5.71 | 4 | 3.2 | 5 | 1 | ||||||
| CYP2E1*5B | 140 |
NR | 206 (NS) |
200 (NS) |
123 (NS) |
375 (P = 0.006) |
||||||
| c1c1 | 139 | 99.93 | – | 198 | 96.12 | 194 | 97 | 122 | 99.2 | 350 | 93 | |
| c1c2 | 1 | 0.07 | 8 | 3.88 | 6 | 3 | 1 | 0.80 | 25 | 7 | ||
| c2c2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| CYP2E1*6 | 140 | 79 (P < 0.001) |
206 (NS) |
200 (P < 0.001) |
123 (P = 0.001) |
375 (P = 0.015) |
||||||
| DD | 128 | 91.43 | 51 | 64.55 | 173 | 83.98 | 138 | 69 | 88 | 71.5 | 305 | 81 |
| DC | 11 | 7.85 | 28 | 35.44 | 32 | 15.53 | 60 | 30 | 31 | 25.25 | 68 | 18 |
| CC | 1 | 0.72 | 0 | 0 | 1 | 0.49 | 2 | 1 | 4 | 3.25 | 2 | 1 |
| Reference | Present study | Saeed et al., 2013 |
Ulusoy et al., 2007 |
Shahriary et al., 2012 | Soya et al., 2005 | Wong et al., 2000 | ||||||
n: Number of subjects. NR: Not reported. NS: Not significant. P values were calculated using the Chi square test and indicate significant difference between the Saudis in the Western region and other populations.