TABLE 1.

Database characteristics.

	Mondriaan	Danish national registries	AOK NORDWEST3	Bavarian claims	BIFAP a	SIDIAP	CPRD a	EGB a
Source population	0.4 m	5.5 m	2.7 m	10.5 m	7.5 m	5.8 m	12.5 m	0.7 m
Year(s) covered for this study	2012–2015	2008–2015	2008–2015	2008–2015	2008–2015	2009–2015	2008–2015	2013–2015
Type of database b	GP prescribing data	Dispensing data from community pharmacies	Claims database including data for dispensed reimbursed drugs	Claims database including data for dispensed reimbursed drugs	General practice prescribing data/reimbursed data	General practice prescribing data/reimbursed data	General practice prescribing data	Claims database including dispensed reimbursed data
Data available since	1991	1994	2007	2008	2001	2006	1987	2004
Demographic variables available
Date of registration	Yes	Yes	Yes	Yes (first consultation)	Yes	Yes	Yes	Yes
Date of transferring out	Yes	Yes	Yes	Yes (last consultation)	Yes	Yes	Yes	Yes
Date of birth	DD-MM-YY	MM-YY	MM-YY	MM-YY	MM-YY	MM-YY	MM-YY	MM-YY
Gender	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Drug information available
Active international coding	ATC	ATC	ATC	ATC	ATC	ATC	BNF	ATC
Product coding	HPK	Nordic Article Number	PZN	PZN	CNF	Yes c	Product code	CIP-13

	Mondriaan	Danish national registries	AOK NORDWEST3	Bavarian claims	BIFAP a	SIDIAP	CPRD a	EGB a
Date of prescribing/dispensing	Yes	Yes	Primary care sector: Yes Secondary care sector: Yes (only for a few selected (expensive) compounds, but no (D)OACs prescriptions)	Yes (for each prescription the quarter is documented)	Yes	Yes d	Yes	Yes
Quantity prescribed/dispensed	Yes	Yes	Yes (package size)	Yes (package size)	Yes	Yes e	Yes	Yes
Dosing regimen	No	No	No	No	Yes	Yes f	Yes	No
Outcome information
Outpatient primary care diagnosis	ICPC	No	ICD-10-GM (quarterly base)	ICD-10-GM (for each diagnosis the quarter is documented)	ICPC-2, ICD-9	ICD-10	ICD-9, ICD-10	ICD-10
Hospital discharge diagnosis	No	ICD-8, ICD-10	ICD-10-GM	No	No	No g	ICD-9, ICD-10	ICD-10
Laboratory tests	Yes	No	No	No	Yes (as requested by GP)	Yes	Yes	No
Mortality	Yes	Yes	No (incompletely recorded, e.g., no follow-up for patients leaving the AOK)	No	Yes (no cause of death)	Yes (no cause of death)	Yes	Yes (no cause of death)

^aRepresentative of general population.

^bPrescribing databases: collected information on prescribed drugs by GP; Reimbursement databases: collected information on dispensed drugs funded by Health Care Services; Dispensing databases: collected all dispensation of prescription drugs regardless of the drug’s reimbursement status Elseviers et al., 2016.

^cis registered but not available for research due to confidentiality reasons.

^dFor dispensing: MM/YY.

^eNumber of reimbursed packages.

^fOnly in prescribing data.

^gAvailable for 28% of included population.