Figure 1. Patient Flow Through the PARALLAX -HF Trial.

^aFour hundred fifty-one patients were screened more than once; rescreened patients were included only once.

^bDefined as any untoward medical occurrence or worsening of preexisting medical conditions or diseases at the time of signing the informed consent form.

^cPatients did not qualify for randomization and did not receive study treatment but were inadvertently randomized into the study.

^dPatients were inadvertently randomized within a wrong treatment stratum and did not receive the study treatment. Rerandomized patients were included only once.

^ePatients with baseline 6-minute walk distance of 100 to 450 m.

NT-proBNP indicates N-terminal pro–brain natriuretic peptide.