Table 2.

Metabolic, biochemical, and coagulation parameters of patients with COVID-19 in the presence or absence of diabetes mellitus (M±σ)

Index	Control group (n=32)	Main group (n=32)	р
Blood glucose on admission (mmol/L)	4.8±0.8	8.1±2.9	0.0000
Creatinine (μmol/L):
on admission	85.9±25.4	98.4±32.7	0.23
days 3–5	98.6±25.6	113.6±33.4	0.035
at discharge	96.2±19.1	95.2±27.9	0.56
pdyn*	0.43	0.020	—
Glomerular filtration rate (ml/min):
on admission	74.7±17.97	65.5±21.8	0.10
days 3–5	64.2±17.6	55.9±19.8	0.09
at discharge	64.7±16.0	67.3±23.0	0.61
pdyn*	0.31	0.067	—
D-dimer (ng/ml):
on admission	824.2±1291.8	986.4±1690.7	0.89
day 2	618.0±1020.4	421.6±632.5	0.81
days 3–5	663.8±1215.3	615.4±987.5	0.92
at discharge	59.1±111.2	31.2±106.9	0.22
pdyn*	0.004	0.0003	—
Day of D-dimer normalization (if abnormal at baseline)	5.6±4.5	9.0±6.3	0.035
Fibrinogen (g/L):
on admission	5.5±1.6	6.0±1.8	0.22
days 3–5	4.4±0.9	5.2±1.2	0.013
at discharge	3.9±0.9	4.0±1.5	0.73
pdyn*	0.00001	0.00001	—
Day of fibrinogen normalization (if abnormal at baseline)	8.3±5.5	11.8±5.5	0.037
APTT (s):
on admission	30.1±6.1	34.9±26.8	0.91
days 3–5	33.7±7.1	40.6±24.8	0.77
at discharge	37.0±17.4	36.9±16.1	0.55
pdyn*	0.004	0.23	—
PTT (s):
on admission	12.8±1.3	13.4±3.7	0.38
days 3–5	12.4±1.6	13.6±4.1	0.064
at discharge	16.4±19.3	12.8±2.9	0.81
pdyn*	0.28	0.019	—
INR:
on admission	1.1±0.1	1.1±0.3	0.51
days 3–5	1.1±0.1	1.1±0.4	0.52
at discharge	1.1±0.3	1.1±0.3	0.92
pdyn*	0.29	0.16	—
Day of INR normalization (if abnormal at baseline)	3.7±4.1	6.1±6.5	0.14
AT III (%):
on admission	107.0±13.7	107.4±19.5	0.64
days 3–5	96.2±13.2	95.4±13.3	0.96
at discharge	96.1±11.7	98.0±13.2	0.64
pdyn*	0.001	0.058	—
Day of AT III normalization (if abnormal at baseline)	1.6±1.9	4.4±5.6	0.012
ALT (units/L):
on admission	36.7±23.7	40.2±25.4	0.56
days 3–5	59.9±55.8	89.6±96.1	0.22
at discharge	58.1±45.6	63.9±78.8	0.91
pdyn*	0.002	0.017	—
AST (units/L):
on admission	34.8±16.6	49.9±44.5	0.16
days 3–5	54.8±46.8	68.5±62.2	0.26
at discharge	37.6±25.4	43.6±29.0	0.62
pdyn*	0.057	0.015	—
CRP (mg/L):
on admission	41.6±37.3	91.3±90.0	0.028
days 3–5	51.1±61.2	97.1±87.3	0.015
days 7–10	53.5±57.3	60.1±65.5	0.86
at discharge	7.3±9.9	10.3±16.7	0.50
pdyn*	0.001	0.00001	—
Hemoglobin (g/L):
on admission	138.1±12.97	137.5±13.8	0.86
at discharge	125.7±16.8	125.5±16.3	0.90
pdyn**	0.0001	0.0003	—
Hematocrit (%):
on admission	40.7±3.7	40.9±3.8	0.61
at discharge	37.7±4.0	37.9±4.5	0.70
pdyn**	0.0001	0.003	—
Leukocytes (×109/L):
on admission	6.3±2.7	6.7±3.1	0.71
at discharge	5.1±1.9	6.2±1.6	0.012
pdyn**	0.021	0.63	—
ESR (mm/h):
on admission	29.3±21.5	34.4±21.3	0.22
at discharge	16.9±10.6	26.0±20.0	0.048
pdyn**	0.007	0.16	—

* p_dyn — significance of the differences between values in dynamics by Friedman;

** — by Wilcoxon.