Table 1.

Recent and in progress clinical trials for chronotherapy in hypertension.

Clinical trial	Participants details	Duration	Study design	In progress?	Results	Reference
Hellenic-Anglo Research into Morning or Night Antihypertensive Drug Delivery (HARMONY; NCT01669928)	103 hypertensive patients (59 men/44 women, 61.8 ± 10.3 years of age)	24 weeks	Patients assigned to ingest ≥ 1 hypertension medication in the morning (6AM-11AM; n=51) or in the evening (6 PM-11 PM; n=52) for 12 weeks then crossed over for remaining 12 weeks. 24 h ambulatory BP monitoring.	No	No significant differences in 24 h, daytime, or nighttime SBP between morning and evening administration of antihypertensive medication.	93
Hygia Chronotherapy (NCT00741585)	19084 hypertensive patients (10614 men/8470 women, 60.5 ± 13.7 years of age)	6.3 years median patient follow-up	Patients assigned to ingest ≥ 1 hypertension medication at bedtime (n=9552) or upon awakening (n=9532). 48 h ambulatory BP monitoring.	No	Reduced nighttime SBP, lower prevalence of non-dipping BP and 45% reduction in primary cardiovascular disease outcome in bedtime ingestion patients, compared with morning dosing.	84
Treatment in Morning versus Evening (TIME; UKCRN1707)	21116 hypertensive patients	4 years	Patients assigned to ingest ≥ 1 hypertension medication in the morning or evening. No ambulatory BP monitoring. Primary end point is hospitalization for the composite end point of non-fatal MI/stroke or vascular death.	Yes		96
Effect of Antihypertensive Medication Timing on Morbidity and Mortality (BedMed; NCT02990663)	3440 hypertensive patients (estimated enrollment)	4 years	Patients assigned to ingest ≥ 1 hypertension medication in the morning or evening.	Yes
BedMed Frail (NCT02990663)	1200 hypertensive patients who are residents in a participating long term care facility (estimated enrollment)	2 years (estimate)	Patients assigned to ingest ≥ 1 hypertension medication in the morning or evening.	Yes