Table 5.

Mean and Adjusted Mean Full Field Hill of Vision (V_TOT)

Models	N=126a	Mean (SD) – decibel steradians	Adjusted Mean (95% CI)- decibel steradiansb	Difference from Reference Group (95% CI)	P-valuec
Clinical Diagnosis					<0.001
USH2	80	22.5 (21.5)	22.9 (17.9, 28.0)	Reference
ARRP	46	37.1 (24.7)	36.3 (29.5, 43.1)	13.4 (4.2, 22.6)
Duration of disease, yrs d					<0.001
<10	36	40.5 (22.6)	39.1 (31.9, 46.3)	Reference
[10,20)	46	28.5 (21.9)	27.9 (21.7, 34.0)	−11.2 (−20.3, −2.1)
>=20	43	15.0 (18.2)	21.9 (13.8, 30.1)	−17.2 (−28.9, −5.4)
Age of enrollment, yrs e					0.02
<35	44	35.7 (23.0)	35.4 (27.1, 43.6)	Reference
35–45	43	23.9 (22.4)	27.7 (21.3, 34.1)	−7.6 (−18.4, 3.1)
>=45	39	23.1 (24.2)	25.8 (18.8, 32.7)	−9.6 (−21.4, 2.2)

^aStatic perimetry results were graded by a reading center. Results are based on the average of 3 fields when 3 tests were performed (primary cohort); otherwise they based on just the 1 test performed (secondary cohort). Static perimetry data is not included for 1 participant in the ARRP group (participant was not tested).

^bSimultaneous adjustment for duration of disease, clinical diagnosis, and age of enrollment

^cFactors are presented categorically to show the data but were analyzed using continuous version of the factor in the model.

^d1 participant in the ARRP group was missing age of onset (a participant-reported field based on their awareness of visual symptoms) and duration of disease (computed based on age of onset and date of enrollment)

^e28 participants were not permitted to report date of birth due to regulatory restrictions. Therefore, only year of birth and categorical age was reported. For those participants, July 1st with the reported birth year was imputed as birth date to calculate continuous age