Table 4.
Alleles and genotypes frequencies of ACE rs4646994, AGT rs699 and AGTR1 rs5186 polymorphisms in COVID-19 patients and control subjects
| Polymorphism | Group | Genotypes, n (%) | Allele, n (%) | HWE | ||||
|---|---|---|---|---|---|---|---|---|
| χ2 | p | |||||||
| DD | DI | II | D | I | ||||
| ACE rs4646994 | Patients | 144 (55.8) | 89 (34.5) | 25 (9.7) | 377 (73.6) | 139 (26.94) | 3.94 | 0.052 |
| Controls | 70 (28.7) | 123 (50.4) | 51 (20.9) | 263 (53.89) | 225 (46.11) | 0.05 | 0.90 | |
| TT | TC | T | C | |||||
| AGT rs699 | Patients | 20 (9.2) | 197 (90.8) | – | 237 (54.61) | 197 (45.39) | 142.9 | < 0.001 |
| Controls | 113 (46.1) | 132 (53.9) | – | 358 (73.06) | 132 (26.94) | 33.3 | < 0.001 | |
| AA | AC | CC | A | C | ||||
| AGTR1 rs5186 | Patients | 154 (74.4) | 49 (23.7) | 4 (1.9) | 357 (86.81) | 57 (13.19) | 0.001 | > 0.99 |
| Controls | 185 (75.8) | 59 (24.2) | 0 | 429 (87.91) | 59 (12.09) | 4.61 | 0.031 | |
Abbreviation: HWE Hardy-Weinberg equilibrium