Table 5.

Genotypes and allele frequencies of ACE rs4646994, ATG rs699 and AGTR1 rs5186 polymorphisms in COVID-19 patients and controls

Polymorphisms	Genetic Models	Patients, n (%)	Control, n (%)	Crude analysis		Adjusted analysisa
ACE rs4646994	Codominant			OR (95% CI)	p	OR (95% CI)	p
	DD	144 (55.8)	70 (28.7)	1.00	–	1.00	–
	ID	89 (34.5)	123 (50.4)	0.35 (0.23–0.52)	< 0.001	0.38 (0.24–0.60)	< 0.001
	II	25 (9.7)	51 (20.9)	0.23 (0.13–0.41)	< 0.001	0.11 (0.05–0.21)	< 0.001
	Dominant
	DD	144 (55.8)	70 (28.7)	1.00	–	1.00	–
	ID + II	114 (44.2)	174 (71.3)	0.31 (0.21–0.46)	< 0.001	0.27 (0.18–0.42)	< 0.001
	Recessive
	DD + ID	233 (90.3)	193 (79.1)	1.00	–	1.00	–
	II	25 (9.7)	51 (20.9)	0.40 (0.24–0.67)	< 0.001	0.18 (0.09–0.34)	< 0.001
	Overdominant
	DD + II	169 (65.5)	121 (49.6)	1.00	–	1.00	–
	ID	89 (34.5)	123 (50.4)	0.51 (0.36–0.74)	< 0.001	0.71 (0.47–1.06)	0.058
	Alleles
	D	377 (73.6)	263 (53.89)	1.00	–	1.00	–
	I	139 (26.94)	225 (46.11)	0.43 (0.33–0.56)	< 0.001	0.32 (0.24–0.43)	< 0.001
ATG rs699	Codominant
	TT	20 (9.2)	113 (46.1)	1.00	–
	TC	197 (90.8)	132 (53.9)	8.43 (4.99–14.24)	< 0.001	18.17 (9.88–33.39)	< 0.001
	Alleles
	T	237 (54.61)	358 (73.06)	1.00	–	1.00	–
	C	197 (45.39)	132 (26.94)	2. 25 (1.71–2.96)	< 0.001	3.61 (2.58–5.05)	< 0.001
ATGR1 rs5186	Codominant
	AA	154 (74.4)	185 (75.8)	1.00	–	1.00	–
	AC	49 (23.7)	59 (24.2)	0.99 (0.64–1.54)	0.5	0.83 (0.51–1.36)	0.28
	CC	4 (1.9)	0	–	–	–	–
	Dominant
	AA	154 (74.4)	185 (75.8)	1.00	–	1.00	–
	AC + CC	53 (25.6)	59 (24.2)	1.07 (0.70–1.65)	0.40	0.90 (0.55–1.45)	0.38
	Recessive
	AA + AC	203 (98.1)	244 (100)	1.00	–	1.00	–
	CC	4 (1.9)	0	–	–	–	–
	Overdominant
	AA + CC	158 (76.3)	185 (75.8)	1.00	–	1.00	–
	AC	49 (23.7)	59 (24.2)	0.97 (0.62–1.50)	0.49	0.82 (0.50–1.33)	0.24
	Alleles
	A	357 (86.81)	429 (87.91)	1.00	–	1.00	–
	C	57 (13.19)	59 (12.09)	1.10 (0.74–1.63)	0.34	0.99 (0.64–1.52)	0.52

^aAdjusted for age and sex