Table 2:

Detectable CSF HIV RNA as a predictor of neurocognitive global and domain T-scores. Longitudinal analysis using linear mixed-effects model, adjusted for confounders.

Outcome (T score)	Predictora	Coefficient (95% CI)	P Value
Global	Detectable HIV RNA, CSF	−0.96 [−1.99, 0.074]	0.070
	Integrase Inhibitor Use	3.89 [1.21, 6.57]	0.005**
	Number of drugs failed	−0.48 [−0.84, −0.12]	0.010*
	Time since baseline (years)	0.45 [0.096, 0.80]	0.013*
Recall	Detectable HIV RNA, CSF	−3.04 [−5.46, −0.63]	0.014*
	Integrase Inhibitor Use	3.88 [−1.27, 9.03]	0.14
	Duration of all ART (months)	−0.020 [−0.045, 0.0053]	0.13
	Time since baseline (years)	−0.017 [−0.83, 0.79]	0.97
Motor	Detectable HIV RNA, CSF	−2.50 [−4.92, −0.075]	0.045*
	Number of drugs failed	−0.75 [−1.27, −0.24]	0.005**
	Time since baseline (years)	0.34 [−0.43, 1.12]	0.39
Processing speed	Detectable HIV RNA, CSF	−1.40 [−3.05, 0.25]	0.098
	Integrase Inhibitor Use	4.15 [−0.065, 8.37]	0.055
	Number of drugs failed	−0.79 [−1.33, −0.25]	0.005**
	Time since baseline (years)	0.63 [0.071, 1.19]	0.028*
Learning	Detectable HIV RNA, CSF	−1.88 [−4.14, 0.38]	0.10
	Integrase Inhibitor Use	5.09 [0.22, 9.96]	0.041*
	Duration of all ART (months)	−0.018 [−0.042, 0.0055]	0.14
	Time since baseline (years)	0.14 [−0.62, 0.90]	0.71
Executive Function	Detectable HIV RNA, CSF	1.78 [−1.04, 4.61]	0.22
	Number of drugs failed	−0.52 [−1.03, −0.003]	0.051
	Time since baseline (years)	2.18 [1.27, 3.10]	<0.001**
Working Memory	Detectable HIV RNA, CSF	0.80 [−0.99, 2.59]	0.38
	Time since baseline (years)	0.25 [−0.31, 0.81]	0.39
Verbal	Detectable HIV RNA, CSF	0.034 [−1.78, 1.85]	0.97
	Integrase Inhibitor Use	4.58 [0.37, 8.79]	0.034*
	Current CD4+ T-cell Countb	0.18 [0.0034, 0.36]	0.047*
	Duration of all ART (months)	−0.018 [−0.044, 0.0076]	0.17
	Time since baseline (years)	−0.11 [−0.75, 0.52]	0.73

^aCSF Detectable RNA and time were forced into the linear mixed-effects models, and current/nadir CD4 counts, duration of all ART, integrase inhibitors (IIs), and NRTIs then entered to the models as covariates; the covariates with p-value ≤ 0.2 were retained in the model; CI= confidence interval; CSF= cerebrospinal fluid; RNA=ribonucleic acid; IIs= Integrase inhibitor therapy; CD= cluster of differentiation; ART= antiretroviral therapy; NRTI= nucleoside reverse transcriptase inhibitor;

^bsquare-root transformation;

^*p<0.05;

^**p<0.01.

For categorical predictors, the coefficient of the linear mixed-effects model is interpreted as difference of mean response (global or domain T-scores) between groups determined by the predictor, all other predictors being held constant.