Table 2.

A. Number of Events, Person-Years, Incidence Rate and Crude Incidence Rate Ratio in the Main Cohort with CAD (N=9,728)
	ARB (N=1053)			ACEI (N=8675)			ARB vs. ACEI
	# events	Person- year	Incidence rate	# events	Person- year	Incidence rate	Crude Incidence Rate Ratio
Death	83	1810.4	45.9 (36.0 – 55.7)	924	15543.6	59.5 (55.6 – 63.3)	0.76 (0.62 – 0.94)
Cardiovascular Death	43	1447.9	29.7 (20.8 – 38.6)	579	13581.6	42.6 (39.2 – 46.1)	0.69 (0.51 – 0.93)
Cardiac Death	38	1447.9	26.3 (17.9 – 34.6)	533	13581.6	39.2 (35.9 – 42.6)	0.66 (0.48 – 0.90)
Sudden Cardiac Death	16	1447.9	11.1 (5.6 – 16.5)	270	13581.6	19.9 (17.5 – 22.3)	0.55 (0.34 – 0.89)
Myocardial Infarction	92	1721.7	53.4 (42.5 – 64.4)	1064	14346.9	74.2 (69.7 – 78.6)	0.70 (0.58 – 0.85)
Stroke	53	1746.0	30.4 (22.2 – 38.5)	418	15017.0	27.8 (25.2 – 30.5)	1.07 (0.81 – 1.43)
Heart Failure	147	1661.2	88.5 (74.2 – 102.8)	1355	13895.4	97.5 (92.3 – 102.7)	0.89 (0.75 – 1.05)
CV hospitalizations	253	1546.4	163.6 (144.6–185.1)	2384	12657.9	188.3 (180.9–196.1)	0.85 (0.75 – 0.96)

B. Number of Events, Person-Years, Incidence Rate and Crude Incidence Rate Ratio in the Main Cohort with HF (N=9,150)
	ARB (N=1066)			ACEI (N=8084)			ARB vs. ACEI
	# events	Person- year	Incidence rate	# events	Person- year	Incidence rate	Incidence Rate Ratio
Death	121	1238.8	97.7 (80.3 – 115.1)	1204	11035.6	109.1 (102.9 – 115.3)	0.86 (0.71 – 1.03)
Cardiovascular Death	59	1052.3	56.1 (41.8 – 70.4)	721	10017.0	72.0 (66.7 – 77.2)	0.75 (0.60 – 0.94)
Cardiac Death	55	1052.3	52.3 (38.5 – 66.1)	649	10017.0	64.8 (59.8 – 69.8)	0.78 (0.61 – 0.98)
Sudden Cardiac Death	15	1052.3	14.3 (7.0 – 21.5)	305	10017.0	30.5 (27.0 – 33.9)	0.45 (0.27 – 0.77)
Myocardial Infarction	54	1206.3	44.8 (32.8 – 56.7)	582	10560.2	55.1 (50.6 – 59.6)	0.78 (0.60 – 1.02)
Stroke	45	1203.1	37.4 (26.5 – 48.3)	370	10769.4	34.4 (30.9 – 37.9)	1.05 (0.79 – 1.40)
Heart Failure	303	986.7	307.1 (272.5 – 341.7)	2206	8854.8	249.1 (238.7 – 259.5)	1.15 (1.02 – 1.29)
CV hospitalizations	361	962.7	378.9(341.8 – 420.1)	2792	8366	333.7(321.6–346.3)	1.07 (0.97 – 1.19)

C. Number of Events, Person-Years, Incidence Rate and Crude Incidence Rate Ratio in the Main Cohort with Stroke (N=2,564)
	ARB (N=522)			ACEI (N=2042)			ARB vs. ACEI
	# events	Person- year	Incidence rate	# events	Person- year	Incidence rate	Incidence Rate Ratio
Death	37	844.5	43.8 (29.7 – 57.9)	166	3360.9	49.4 (41.9 – 56.9)	0.88 (0.61 – 1.28)
Cardio-vascular Death	18	685.3	26.3 (14.1 – 38.4)	88	2947.9	29.9 (23.6 – 36.1)	0.87 (0.54 – 1.40)
Cardiac Death	12	685.3	17.5 (7.6 – 27.4)	55	2947.9	18.7 (13.7 – 23.6)	0.92 (0.51 – 1.69)
Sudden Cardiac Death	8	685.3	11.7 (3.6 – 19.8)	25	2947.9	8.5 (5.2 – 11.8)	1.34 (0.63 – 2.85)
Myocardial Infarction	23	825.4	27.9 (16.5 – 39.3)	100	3269.2	30.6 (24.6 – 36.6)	0.91 (0.61 – 1.37)
Stroke	59	794.4	74.3 (55.3 – 93.2)	290	2986.0	97.1 (85.9 – 108.3)	0.76 (0.58 – 0.99)
Heart Failure	30	820.5	36.6 (23.5 – 49.6)	122	3229.7	37.8 (31.1 – 44.5)	0.95 (0.65 – 1.40)
CV hospitalizations	96	761.9	126.0(103.1–153.9)	459	2819.4	162.8(148.6–178.4)	0.78 (0.63 – 0.95)

Incidence rate: per 10,000 person –years