FIGURE 1.
The main trials testing drug therapy after the publication of the last European Society of Cardiology Guidelines. 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 87 , 93 , 94 The distribution of the trials is based on the year of publication and the left ventricular ejection fraction at the time of the enrolment (the mean and range follow the inclusion criteria). The different colours identify the different drugs tested. ESC, European Society of Cardiology; HFmrEF, heart failure with mid‐range ejection fraction; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; LVEF, left ventricular ejection fraction