FIGURE 2.
The results of the CARMEN 38 and PROVE‐HF 3 studies. The first study compared the reverse remodelling and improvement of the left ventricular ejection fraction in patients undergoing treatment with enalapril, carvedilol and enalapril plus carvedilol for up to 18 months. The second tested the introduction of sacubitril‐valsartan in patients with heart failure with reduced ejection fraction who have already been treated with beta blockers and, in part, mineralocorticoid receptor antagonists, 75.8% of whom were previously treated with ACEi or angiotensin II receptor blockers. LVEF, left ventricular ejection fraction; LVESVI, left ventricular end‐systolic volume index