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Therapeutic target of pharmacological treatment in patients with heart failure with reduced ejection fraction. ACEi and ARBs should be prescribed when ARNi are not tolerated. ACEi, ACE inhibitor; ARBs, Angiotensin II receptor blockers; ARNi, angiotensin receptor neprilysin inhibitor; HFrEF, heart failure with reduced ejection fraction; HR, heart rate; MRA, mineralocorticoid receptor antagonists; SGLT2i, sodium‐glucose cotransporter‐2 inhibitor
