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. 2021 Nov 2;12:767981. doi: 10.3389/fimmu.2021.767981

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Copyright © 2021 Jarlhelt, Nielsen, Jahn, Hansen, Pérez-Alós, Rosbjerg, Bayarri-Olmos, Skjoedt and Garred

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of depletion of antibodies against RBD. Plasma from three recovered convalescent individuals and healthy control individuals was depleted for anti-RBD antibodies and subjected to the following assays; (A) an RBD specific sandwich ELISA, (B) a spike specific sandwich ELISA, (C) a neutralizing assay and (D) a complement deposition assay, with spike as the antigen. The RBD and spike specific assays utilized plates coated with RBD or spike (1 µg/ml) and HRP-conjugated polyclonal rabbit antibodies against human IgM, IgA, or IgG (1 µg/ml) for detection. A p value < 0.05 was considered significant. ****p < 0.0001 using an ordinary one-way-ANOVA with Holm-Šídák’s multiple comparisons test. Data are represented as mean values of two independent measurements.