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(a) T1 relaxation time of three different solutions containing the same amount of Mn ions as measured with a 0.47 T NMR relaxometer. Reported values are a mean of three replicates ± SD. ****P < 0.001 (Student’s t-test) vs MnCl2, (b) T1-weighted images of Mn@HFn-RT, Mn@HFn-HT, and GdDTPA containing the same concentration of metal (0.1 mM), and (c) T1-weighted images of Mn@HFn-RT and Mn@HFn-HT containing the same concentration of HFn (0.1 mg/mL).
