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. 2021 Jun 15;129(5):e12800. doi: 10.1111/eos.12800

TABLE 2.

Risk of bias assessment of the included randomized controlled trials

Study name (year) Revised Cochrane risk‐of‐bias tool for randomized trials (RoB 2)
Domain 1 Domain 2 Domain 3 Domain 4 Domain 5 Overall risk‐of‐bias
Matthews et al. (2003) [50] SC L L L L SC
Norholt et al. (2004) [14] SC L L L L SC
Cheung et al. (2004) [17] SC L SC SC L SC
Ueki et al. (2005) [19] SC L L L L SC
Cheung et al. (2008) [54] SC L H L L H
Park et al. (2010) [20] SC L L L SC SC
Stockmann et al. (2010) [13] SC L L L L SC
Tuovinen et al. (2010) [15] SC L L L L SC
Buijs et al. (2012) [55] L H L L L H
Yoshioka et al. (2012) [18] SC L H H L H
Bakelen et al. (2013) [56] L H L L L H
Yu et al. (2014) [16] H L SC L SC H
Bakelen et al. (2015) [57] L H L L L H
Gareb et al. (2017) [2] L H L L L H

Domain 1, Bias arising from the randomization process; Domain 2, Bias due to deviations from the intended intervention; Domain 3, Bias due to missing outcome data; Domain 4, Bias in measurement of outcome; Domain 5, Bias in selection of reported results; H, high risk of bias; L, low risk of bias; SC, some concerns.