Figure 2.

Definitions of remission (A) and low disease activity (B) used in the studies for randomized controlled trials (solid bars) and nonrandomized studies (shaded bars). Some studies compared different treatment goals. ACR = American College of Rheumatology; CDAI = Clinical Disease Activity Index; CRP = C‐reactive protein; DAS28 = Disease Activity Score in 28 joints; ESR = erythrocyte sedimentation rate; EULAR = European Alliance of Associations for Rheumatology; SDAI = Simplified Disease Activity Index.