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Summary demographics and baseline characteristics, mean (SD)
| Part A (n = 10) | Part B (n = 33) | |
|---|---|---|
| Age, years | 70.2 (3.6) | 70 (5.0) |
| Weight, kg | 74.8 (12.3) | 74.2 (8.7) |
| BMI, kg/m2 | 25.5 (3.7) | 25.5 (2.5) |
| Gender, n (%) | ||
| Female | 5 (50) | 17 (52) |
| Male | 5 (50) | 16 (48) |
| CYP2D6 predicted phenotype, n (%) | ||
| Extensive metabolizer | 10 (100) | 27 (82) |
| Intermediate metabolizer | 0 | 6 (18) |
| Cognitive score at screening < 1 SD, n (%) | ||
| Word fluency | N/A | 12 (36) |
| AVLT | N/A | 13 (39) |
| Adaptive tracking test | N/A | 14 (42) |
