TABLE 3.

Oral PK of HTL0009936 at 24 mg, mean (%CV) or [range] for n = 6

Dose (mg)	T max (hr)	C max (ng/mL)	AUC0–24 (h.ng/mL)	AUC0‐∞ (hr.ng/ml)	t½ po (hr)	Fpo (%) a
24	1.0 [0.50–1.5]	14.1 (49)	44.1 (48)	47.2 (41)	2.4 (28)	14.8 (44) [8.7–27]

Geometric mean and (geometric %CV) except T _max median [minimum − maximum] for n = 6. AUC_0‐∞, area under the plasma concentration–time curve from zero extrapolated to infinity; AUC_0–24, area under the plasma concentration–time curve from zero to 24 hours post dose; C _max, maximum plasma concentration; Fpo, oral bioavailability and [minimum − maximum]; T _max, time to C _max; t_½ po, apparent terminal half‐life after oral administration.

^a Oral bioavailability estimated in comparison with 10 mg IV single infusion.