TABLE 3.
Mortality among cases with congenital anomalies according to type of anomaly (n = 8535, perinatal mortality in grey); Eurocat Northern Netherlands, 2001–2017
| Total cases | Early foetal mortality | Late foetal mortality | Early neonatal mortality | Total mortality | |||
|---|---|---|---|---|---|---|---|
| spontaneous | TOPFA | spontaneous | TOPFA | 0–7 days | |||
| Type of anomaly | N | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) |
| Structural anomalies | 5746 | 37 (0.6) | 286 (5.0) | 49 (0.9) | 6 (0.1) | 77 (1.3) | 455 (7.9) |
| Central nervous | 330 | 2 (0.6) | 145 (43.9) | 12 (3.6) | 2 (0.6) | 25 (7.6) | 186 (56.4) |
| Cardiac and circulatory | 1615 | 4 (0.2) | 60 (3.7) | 16 (1.0) | 1 (0.1) | 26 (1.6) | 107 (6.6) |
| Digestive | 596 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.2) | 1 (0.2) |
| Urogenital | 1422 | 6 (0.4) | 43 (3.0) | 11 (0.8) | 2 (0.1) | 13 (0.9) | 75 (5.3) |
| Orofacial clefts | 447 | 3 (0.7) | 5 (1.1) | 1 (0.2) | 1 (0.2) | 0 (0.0) | 10 (2.2) |
| Musculoskeletal | 929 | 5 (0.5) | 2 (0.2) | 2 (0.2) | 0 (0.0) | 0 (0.0) | 9 (1.0) |
| Other | 407 | 17 (4.2) | 31 (7.6) | 7 (1.7) | 0 (0.0) | 12 (2.9) | 67 (16.5) |
| MCA | 466 | 16 (3.4) | 72 (15.5) | 21 (4.5) | 1 (0.2) | 28 (6.0) | 138 (29.6) |
| Abnormal karyotype | 961 | 71 (7.4) | 450 (46.8) | 51 (5.3) | 7 (0.7) | 28 (2.9) | 607 (63.2) |
| Other syndromes | 1362 | 21 (1.5) | 189 (13.9) | 26 (1.9) | 4 (0.3) | 49 (3.6) | 289 (21.2) |
| Total | 8535 | 145 (1.7) | 997 (11.7) | 147 (1.7) | 18 (0.2) | 182 (2.1) | 347 (17.4) |
Abbreviations: MCA, multiple congenital anomalies TOPFA, elective termination of pregnancy for foetal anomalies.
Note: The Grey Shade terms definitions are Late foetal mortality: Foetal death (spontaneous and elective) and stillbirths at or after 24 completed weeks of gestation, Early neonatal mortality: Death in live births (at or after 24 completed weeks of gestation) until day 7 after birth, Early foetal mortality: Foetal death (spontaneous and elective) and stillbirths before 24 completed weeks of gestation.