FIGURE 1.

Outline of N‐glycan classes. N‐glycans share a core sequence (Manα1–3(Manα1–6)Manβ1‐4GlcNAcβ1–4GlcNAcβ1–Asn) that can be extended and classified into three different types (a–c). Examples representing (a) Oligo‐mannose (also called high mannose); (b) complex; (c) hybrid; (d) paucimannose and (e) bisecting GlcNAc (the first mannose in the core extended with a single GlcNAc) structures are shown. In the oligomannose structure the N‐glycan core is marked inside a dashed red square (a). The bisecting GlcNAc is also marked with a red dashed square for clarity (e). Symbol nomenclature as suggested in (Varki et al., 2009). GlcNAc, N‐acetylglucosamine; Sia, sialic acid; Gal, galactose; Man, mannose; Fuc, fucose