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. 2021 Sep 12;22(21):3049–3059. doi: 10.1002/cbic.202100287

Figure 1.

Figure 1

Scheme for selection of PHF6*‐binding peptides using mirror image phage display. (A) The largest human Tau isoform (Tau 2 N4R) in the central nervous systems contains four microtubule binding repeats. PHF6*, consisting of amino acids 275 to 280, is located at the beginning of repeat two. [18] (B) The D‐enantiomeric form of PHF6* was synthesized. After fibrillization, the D‐enantiomeric fibrils were used for phage display. An L‐peptide, binding to the D‐enantiomeric PHF6* fibrils, was selected and the D‐enantiomeric version of the selected L‐peptide was synthesized, which will bind to the L‐enantiomeric form of the target, regular PHF6* fibrils.