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. 2021 Nov 17;14:159. doi: 10.1186/s13048-021-00913-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Wnt/β-catenin signaling is involved in CXCL14-facilitated ovarian OC cell EMT and invasion. A Western blot analysis of the indicated expression levels (β-catenin, cyclin D1, MMP-7, Axin2) in CXCL14 overexpressing SKOV3 and OVCAR3 cells treated with XAV939 (10 μM). B Determination of the proliferative capability of CXCL14 overexpressing SKOV3 and OVCAR3 cells treated with XAV939 using the CCK-8. C Determination of the proliferative capability of CXCL14 overexpressing SKOV3 and OVCAR3 cells treated with XAV939 using the colony formation assay. D Determination of the migration capability of OC cells using the wound healing assay. Scale bar: 200 μm. E Determination of the invasive capability of OC cells using the Transwell assay. Scale bar: 200 μm. ^**P < 0.01 compared with vector, ^##P < 0.01 compared with CXCL14-OE. F-H Statistical analysis of the correlation between CXCL14 and Wnt/β-catenin target genes (Cyclin D1, MMP-7, Axin2) in OC patients (n = 379) cohort using TCGA database