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. 2021 Nov 17;19:365. doi: 10.1186/s12951-021-01109-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A The in vivo biodistribution of IR-780 and IR-780@MPDA at different time points (0, 2, 4, 6, 8, and 12 h) after i.v. injection. B The fluorescence intensities of tumors at different time points after i.v. injection of IR-780 or IR-780@MPDA. Asterisk * indicated p < 0.05. C PA imaging in vivo at 0, 2, 4, 6, 8, and 12 h by using indicated contrast agents. D The relative PA intensities of tumors at different time points after i.v. injection of IR-780, MPDA or IR-780@MPDA