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. 2021 Nov 16;40:365. doi: 10.1186/s13046-021-02169-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — LINC00460 promotes CRC cell migration, invasion and supports the proper function of the EMT transcription program and the location of LINC00460 in CRC cells. a, b, c, d The ability of migration and invasion in HCT116 and SW480 cells ± LINC00460 KD/OE (***p < 0.001). e, f, g, h Relative mRNA expression levels of LINC00460 and EMT markers in HCT116 and SW480 cells ± LINC00460 KD/OE. The relative mRNA expression levels were normalized to GAPDH (*p < 0.05, **p < 0.01, ***p < 0.001). i, j Western blots of EMT markers in HCT116 and SW620 cells ± LINC00460 KD/OE. GAPDH was used as a loading control