Intravenous self-administration task (IVSA) is restored by α5WT, but not α5SNP re-expression in DA neurons. (a) (Left) Mean ± s.e.m A-NP/P-NP ratio for α5−/−-Lv-α5WT (green) and α5−/−-Lv-α5SNP (purple) mice acutely self-administering nicotine (μg kg−1 per infusion). (Right) Mean ± s.e.m of total nicotine intake (mg kg−1) by A mice. (b) (Left) Mean ± s.e.m A-NP/P-NP ratio for α5−/−-DATCre-Lv-α5WT (green) and α5−/−-Lv-α5−/−-DATCre-Lv-α5SNP (purple) mice acutely self-administering nicotine (μg kg−1 per infusion). (Right) Mean ± s.e.m of total nicotine intake (mg kg−1) by A mice. ***P<0.001, **P<0.01, *P<0.05, Student’s t-test. n, number of recorded of mice tested.