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Kaplan‐Meier estimates of the cumulative risk of knee replacement (A) or hip replacement (B) from the time of plasma collection, based on plasma cartilage acidic protein 1 levels and age, sex, and body mass index (top). Cumulative number of joint replacement events over time according to quintiles of risk score among participants (bottom). OA progressed to hip replacement in 376 patients, and to knee replacement in 672 patients.
