FIGURE 7.
A‐subtype and B‐subtype expression in renal vascular and tubular compartments. Biopsies obtained from blood group A1 (panels A–D) and blood group B (panels E–H) kidney grafts in ABO‐O recipients at 1–3 months posttransplant were stained for expression of A‐ and B‐subtype structures. Vascular endothelial cells (glomeruli and peritubular capillaries) express only subtype II A or B antigens (panels D and H, respectively). Tubular epithelial cells of ABO‐A kidneys express A‐subtypes II, III/IV (positive staining in panels C and D), whereas in ABO‐B kidneys tubular epithelial cells express only B‐subtype II antigens (negative staining in panel G, positive staining in panel H). Representative images are of immunohistochemistry staining of ABO‐A1 (n = 4) and ABO‐B (n = 4) kidney grafts. Monoclonal antibody specificities 22 : Z2B‐1: A‐I, II, III/IV. 89F: B‐I, II, IV. JTL‐2: A‐III/IV, B‐III/IV, H‐III/IV. JTL‐4: A‐II and B‐II